4-Chloro-6,7-dimethoxyquinazoline synthesis
- Product Name:4-Chloro-6,7-dimethoxyquinazoline
- CAS Number:13790-39-1
- Molecular formula:C10H9ClN2O2
- Molecular Weight:224.64
13794-72-4
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$8.00/1g
13790-39-1
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$10.00/1g
Yield:13790-39-1 98%
Reaction Conditions:
with thionyl chloride in N,N-dimethyl-formamide for 6 h;Heating / reflux;
Steps:
1.b Example 1
b) Dimethylformamide (0.2 ml) was added dropwise to a solution of 6,7-dimethoxy-3,4-dihydro-quinazolin-4-one (10.0 g, 48.5 mmol) in thionyl chloride (200ml) and the reaction was heated at reflux for 6 hours. The reaction was cooled, excess thionyl chloride was removed in vacuo and the residue was azeotroped with toluene (2 x 50 ml) to remove the last of the thionyl chloride. The residue was taken up in dichloromethane (550 ml), the solution was washed with i) saturated aqueous sodium hydrogen carbonate solution (2 x 250 ml) and ii) brine, and the organic phase was dried over magnesium sulphate. Solvent evaporation in vacuo yielded 4-chloro-6,7-dimethoxyquinazoline (10.7 g, 98 % yield) as a white solid: 1H-NMR (DMSO d6): 8.86 (s, 1H), 7.42 (s, 1H), 7.37 (s, 1H), 4.00 (s, 3H), 3.98 (s, 3H): MS (+ve ESI): 225 (M-H)+.
References:
AstraZeneca AB EP1218357, 2005, B1 Location in patent:Page/Page column 14
13794-72-4
290 suppliers
$8.00/1g
13790-39-1
288 suppliers
$10.00/1g
13794-72-4
290 suppliers
$8.00/1g
13790-39-1
288 suppliers
$10.00/1g
26759-46-6
211 suppliers
$6.00/5g
13790-39-1
288 suppliers
$10.00/1g
5653-40-7
285 suppliers
$12.50/5 g
13790-39-1
288 suppliers
$10.00/1g