4-Hydroxy-3-mesityl-1-oxaspiro(4.4)non-3-en-2-one synthesis
- Product Name:4-Hydroxy-3-mesityl-1-oxaspiro(4.4)non-3-en-2-one
- CAS Number:148476-30-6
- Molecular formula:C17H20O3
- Molecular Weight:272.34
4408-60-0
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41248-23-1
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$64.00/100mg
148476-30-6
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$180.00/10mg
Yield:148476-30-6 85%
Reaction Conditions:
Stage #1: 2-mesitylacetic acid;hydroxycyclopentanecarboxylic acid ethyl esterwith trichlorophosphate in toluene at 20;
Stage #2: with sodium hydroxide in toluene; for 8 h;Reflux;
Steps:
1.2; 2 2. Synthesis of 3-(2,4,6-trimethylphenyl)-2-oxo-1-oxaspiro[4,4]indole-3-en-4-ol
474 g (3.0 mol) of ethyl hydroxycyclopentacarboxylate, 551.8 g (3.1 mol) of 2,4,6-trimethylphenylacetic acid dissolvedIn a 1500 mL toluene solution, 822.0 g (6.0 mol) of phosphorus trichloride was added dropwise at room temperature, and the addition was continued at room temperature.Stir overnight, add 450 mL of saturated ammonium chloride solution, separate the organic layer, then add 140.0 g (3.5 mol) into sodium hydroxide, addHeat reflux for 8 h. At the same time, the produced by-product ethanol is distilled off, the reaction is completed, cooled to room temperature, and the reactant is neutralized to pH with concentrated hydrochloric acid.=5-6, then washed with water, dried over anhydrous sodium sulfate and evaporated.943.5 g, yield 85%.
References:
CN109020936,2018,A Location in patent:Paragraph 0024-0027; 0030; 0031
361366-15-6
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148476-30-6
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$180.00/10mg
16841-19-3
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148476-30-6
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5117-85-1
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148476-30-6
27 suppliers
$180.00/10mg
41248-23-1
74 suppliers
$64.00/100mg
148476-30-6
27 suppliers
$180.00/10mg