4'-Hydroxyvalerophenone synthesis
- Product Name:4'-Hydroxyvalerophenone
- CAS Number:2589-71-1
- Molecular formula:C11H14O2
- Molecular Weight:178.23
638-29-9
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108-95-2
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2589-71-1
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Yield:2589-71-1 98%
Reaction Conditions:
with trifluorormethanesulfonic acid at 0 - 20; for 1 h;regiospecific reaction;Friedel-Crafts acylation;
Steps:
4.3. General procedure of Friedel-Crafts acylation of phenols in TfOH
General procedure: Phenol (0.28 mmol) and acyl chloride (0.28 mmol) were dissolved in TfOH (3 ml) at 0 °C. The reaction mixture was warmed to room temperature for appropriate time in Table 2, then poured into cold water and ethyl acetate. The organic layer was washed with 1 M HCl, saturated NaHCO3, and saturated NaCl, and dried over MgSO4, then filtrated. The filtrate was concentrated and the residue was subjected silica column chromatography to afford acylated products. All spectral data were identical with the literatures.27
References:
Murashige, Ryo;Hayashi, Yuka;Ohmori, Syo;Torii, Ayuko;Aizu, Yoko;Muto, Yasuyuki;Murai, Yuta;Oda, Yuji;Hashimoto, Makoto [Tetrahedron,2011,vol. 67,# 3,p. 641 - 649] Location in patent:experimental part
638-29-9
276 suppliers
$14.14/1gm:
2589-71-1
242 suppliers
$7.00/5g
108-95-2
764 suppliers
$14.00/25g
2589-71-1
242 suppliers
$7.00/5g
