4-ISOPROPYL-BENZOIC ACID HYDRAZIDE synthesis
- Product Name:4-ISOPROPYL-BENZOIC ACID HYDRAZIDE
- CAS Number:5351-24-6
- Molecular formula:C10H14N2O
- Molecular Weight:178.23
21900-62-9
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Yield:5351-24-6 85%
Reaction Conditions:
with hydrazine hydrate in ethanol; for 24 h;Reflux;
Steps:
4.2.3. General Procedure for the Synthesis of 4-Substituted Benzoic Acid Hydrazides 6,7
General procedure: The synthesis of 4-substituted benzoic acid hydrazides was performed as previously described [18]. To a solution of ethyl 4-substituted benzoyl chloride4,5(10 mmol) in ethanol (10 mL), excess hydrazine monohydrate (5 mL) was added. The reaction mixture was refluxed for 24 h, and left to cool to room temperature. The formed precipitate was collected by filtration, washed with water followed by cold ethanol to remove excess hydrazine and left to dry to give the corresponding acid hydrazide. 4-Isopropyl-benzoic acid hydrazide(6). Yield 85%,1H-NMR (DMSO-d6): δ 1.21 (d, 6H, 2 CH3of isopropyl), 2.93 (m, 1H, CH of isopropyl), 4.45 (s, 2H, NH2), 7.31 (d, 2H,J= 8, ArH), 7.54 (d, 2H,J= 6.5, ArH), 9.67 (s, 1H, NH).
References:
Fayed, Bahgat;Haider, Mohamed;Hamdy, Rania;Hamoda, Alshaimaa M.;Rawas-Qalaji, Mutasem;Soliman, Sameh S. M. [Molecules,2020,vol. 25,# 6]
536-66-3
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19024-50-1
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