4-METHYL-3-METHYLAMINOPYRIDINE synthesis
- Product Name:4-METHYL-3-METHYLAMINOPYRIDINE
- CAS Number:77862-24-9
- Molecular formula:C7H10N2
- Molecular Weight:122.17
Yield: 87%
Reaction Conditions:
with copper;sodium hydroxide in water at 120 - 130; for 24 h;Autoclave;
Steps:
2 Preparation of compound III
Add compound II (100g, 0.58mol) and water (350g) into the autoclave,Add methylamine hydrochloride (196g, 2.90mol) and sodium hydroxide (120g, 3.0mol) sequentially.Add catalytic amount of copper powder under stirring. The temperature was slowly raised to 120-130°C, and the reaction was stirred for 24 hours.Cool to room temperature, extract three times with dichloromethane (500mL), dry,Concentrated to obtain compound III (61.6 g, yield 87%).
References:
CN112250615, 2021, A Location in patent:Paragraph 0046; 0060-0062
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