(2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER synthesis
- Product Name:(2-BROMO-PYRIDIN-4-YL)CARBAMIC ACID TERT-BUTYL ESTER
- CAS Number:433711-95-6
- Molecular formula:C10H13BrN2O2
- Molecular Weight:273.13
6945-67-1
181 suppliers
$14.00/1g
24424-99-5
863 suppliers
$13.50/25G
433711-95-6
96 suppliers
$22.00/250mg
Yield:-
Reaction Conditions:
with triethylamine in dichloromethane at 0 - 40; for 4 h;
Steps:
75.1 Step 1 Preparation of (2-bromopyridin-4-yl)carbamic acid tert-butyl ester
Take 2-bromo-4-aminopyridine (8.651g, 50.0mmol), triethylamine (15.179g, 150mmol)And dichloromethane (50mL) placed in the reaction flask, weigh di-tert-butyl carbonate(16.369g, 75.0mmol), added to the above reaction flask at 0 , add,The reaction was stirred at 40°C for 4h. After the reaction is complete, cool to room temperature,Add saturated sodium bicarbonate solution and dichloromethane to the reaction system, extract,Take the organic phase and dry with anhydrous sodium sulfate. After concentration under reduced pressure and purification by column chromatography, the title compound was obtained.
References:
Nanjing Shenghe Pharmaceutical Co., Ltd.;Wang Yong;Zhao Liwen;Wang Yazhou;Quan Xu;Liu Haixuan;Wang Xiaowei;Zhang Yan;Li Xue;Cao Chen;Guo Zhuang;Lv Kunzhi;Wang Hai;Zheng Guochuang CN111196804, 2020, A Location in patent:Paragraph 0783; 0785-0787
7598-35-8
370 suppliers
$6.00/250mg
24424-99-5
863 suppliers
$13.50/25G
433711-95-6
96 suppliers
$22.00/250mg