5,6,7,8-TETRAHYDRO-2-NAPHTHOIC ACID synthesis
- Product Name:5,6,7,8-TETRAHYDRO-2-NAPHTHOIC ACID
- CAS Number:1131-63-1
- Molecular formula:C11H12O2
- Molecular Weight:176.21
105482-57-3
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1131-63-1
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Yield:1131-63-1 95%
Reaction Conditions:
Stage #1:ethyl 5,6,7,8-tetrahydronaphthalene-2-carboxylate with sodium hydroxide;water in tetrahydrofuran at 60; for 20 h;
Stage #2: with hydrogenchloride in water; pH=3 - 5
Steps:
24
A solution of compound 1-29 (5.6 g, 1 eq.) in THF (70 mL) was treated with a1 N aqueous NaOH solution (80 mL). The resulting mixture was warmed at 600C for o 20 hours, and then diluted with diethyl ether. After the mixture was extracted twice with a saturated aqueous NaHCθ3 solution, 10% HCl was added to neutralize the mixture to PH= 3~5. The aqueous layer was then extracted with diethyl ether. The combined diethyl ether layer was dried over Na2SO4, filtered, and concentrated to give compound I -30 (4.66 g, 95%). 1H NMR(CDCl3) δ.7.81-7.78 (m, 2H), 7.16-7.13 5 (d, J = 7.5 Hz, IH), 2.82 (m, 4H), 1.84-1.80 (m, 4H). ESI-M S (M+H+) = 177.
References:
TAIGEN BIOTECHNOLOGY CO. LTD. WO2008/95058, 2008, A1 Location in patent:Page/Page column 37-38
93-09-4
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23194-33-4
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774-55-0
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1131-63-1
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124-38-9
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6134-55-0
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6134-56-1
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4242-18-6
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1131-63-1
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