5-Acetonyl-2-methoxybenzene sulfonamide synthesis
- Product Name:5-Acetonyl-2-methoxybenzene sulfonamide
- CAS Number:116091-63-5
- Molecular formula:C10H13NO4S
- Molecular Weight:243.28
80223-79-6
116091-63-5
General procedure for the synthesis of 2-methoxy-5-(2-oxopropyl)benzenesulfonamide from 2-methoxy-5-(2-oxopropyl)benzenesulfonyl chloride: embodiment 6-comparison; method for the preparation of tamsulosin (II) according to the prior art as compared to the method comprising steps according to the present invention.1. Method according to the prior art: 1.1 According to US 4,731,478 (1988) , chlorosulfonation is carried out in two steps; 1.2 The yield of VII is 40% and the total yield of III is 30%.
80223-79-6
18 suppliers
inquiry
116091-63-5
237 suppliers
$5.00/1g
Yield: 74%
Reaction Conditions:
with ammonia in tetrahydrofuran;water
Steps:
6.1.1
Example 6 - comparative; A method of preparation of tamsulosin (II) according to the prior art in comparison with the method with included steps according to the invention 1. The method according to the prior art; 1. 1. Chlorosulfonation in two steps according to US 4,731, 478 (1988); 1.2. VII yield 40% yield 74% III total yield 30%
References:
ZENTIVA, A.S. WO2005/75415, 2005, A1 Location in patent:Page/Page column 9
122-84-9
477 suppliers
$5.00/5g
116091-63-5
237 suppliers
$5.00/1g