5-BROMO-2-ETHOXY-BENZENESULFONYL CHLORIDE synthesis
- Product Name:5-BROMO-2-ETHOXY-BENZENESULFONYL CHLORIDE
- CAS Number:379255-01-3
- Molecular formula:C8H8BrClO3S
- Molecular Weight:299.57
588-96-5
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379255-01-3
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$50.00/50mg
Yield:379255-01-3 43.3%
Reaction Conditions:
with chlorosulfonic acid at -10; for 0.333333 h;
Steps:
2
General procedure for Compound 2: Compound 1 was taken in a two necked flask (2.00 g, 0.0099 moles, 1 eq). Chlorosulfonic acid (25 mL, 0.358 moles, 36 eq) was added slowly over a period of 10 min at -10° C. The resulting mixture was stirred at the same temperature for 10 min. After completion of the starting material, the reaction mixture was poured into ice cold water (100 mL) and extracted with ethyl acetate. The organic layer was washed with H2O, dried over Na2SO4 and concentrated under reduced pressure. The desired product 2 was obtained by column purification (60-120 mesh silica gel, 5% ethyl acetate-hexane) as a solid (3 g, 43.3%).
References:
US2010/331307,2010,A1 Location in patent:Page/Page column 17-18
106-41-2
501 suppliers
$13.00/5g
379255-01-3
28 suppliers
$50.00/50mg