ChemicalBook CAS DataBase List 5-Bromo-2-methoxypyrimidine

5-Bromo-2-methoxypyrimidine synthesis

6synthesis methods

Product Name:5-Bromo-2-methoxypyrimidine
CAS Number:14001-66-2
Molecular formula:C5H5BrN2O
Molecular Weight:189.01

124-41-4

32779-36-5

14001-66-2

Synthesis of compound 11-3 (5-bromo-2-methoxypyrimidine): to a solution of 5-bromo-2-chloropyrimidine (11-2, 2.0 g, 10 mmol) in methanol (15 mL) was added sodium methanolate (CH3ONa, 2.16 g, 40 mmol). The reaction mixture was stirred at 70 °C overnight. Upon completion of the reaction, methanol was removed by rotary evaporator under reduced pressure. Water (10 mL) was slowly added to the residue, followed by extraction with ethyl acetate (300 mL x 3). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated to give 11-3 as a yellow solid (1.17 g, 60% yield).

124-41-4 Synthesis

124-41-4
726 suppliers
$12.00/25g

32779-36-5 Synthesis

32779-36-5
647 suppliers
$5.00/5g

14001-66-2
253 suppliers
$7.00/1g

Yield:14001-66-2 60%

Reaction Conditions:

with methanol at 70;

Steps:

1
Synthesis of Compound 11-3 (0400) To a solution of 11-2 (2.0 g, 10 mmol) in methanol (15 mL) was added CH₃ONa (2.16 g, 40 mmol). The resulting mixture was stirred at 70° C. overnight. Methanol was evaporated in vacuum. Water (10 mL) was added carefully to the residue and the mixture was extracted with ethyl acetate (300 mL×3). The combined organic layers were dried over Na₂SO₄, filtered and concentrated to afford 11-3 as a yellow solid (1.17 g, 60%).

References:

Nivalis Therapeutics, Inc.;Wasley, Jan;Rosenthal, Gary J.;Sun, Xicheng;Strong, Sarah;Qiu, Jian US9138427, 2015, B2 Location in patent:Page/Page column 289-290

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67-56-1 Synthesis