5-CHLOROPYRIDINE-2-BORONIC ACID PINACOL ESTER synthesis
- Product Name:5-CHLOROPYRIDINE-2-BORONIC ACID PINACOL ESTER
- CAS Number:652148-93-1
- Molecular formula:C11H15BClNO2
- Molecular Weight:239.51
40473-01-6
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$5.00/1g
76-09-5
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$10.00/1g
652148-93-1
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$60.00/50mg
Yield:652148-93-1 47%
Reaction Conditions:
Stage #1: 2-Bromo-5-chloro-pyridinewith n-butyllithium in tetrahydrofuran at -78;
Stage #2: with Triisopropyl borate in tetrahydrofuran at -78 - 20;
Stage #3: 2,3-dimethyl-2,3-butane diolwith acetic acid in tetrahydrofuran;
References:
Bouillon, Alexandre;Lancelot, Jean-Charles;Santos, Jana Sopkova De Oliveira;Collot, Valérie;Bovy, Philipppe R.;Rault, Sylvain [Tetrahedron,2003,vol. 59,# 50,p. 10043 - 10049]