ChemicalBook CAS DataBase List 6-(Trifluoromethyl)nicotinic acid

6-(Trifluoromethyl)nicotinic acid synthesis

4synthesis methods

Product Name:6-(Trifluoromethyl)nicotinic acid
CAS Number:231291-22-8
Molecular formula:C7H4F3NO2
Molecular Weight:191.11

216431-85-5

231291-22-8

To a 10L three-necked flask were added 1420 g of water, 2440 g of sulfuric acid, and 150 mL of glacial acetic acid, and 870 g (5 mol) of 6-(trifluoromethyl)nicotinonitrile was added slowly. The mixture was heated to reflux and kept overnight. Upon completion of the reaction, the reaction mixture was cooled, ice was added and the mixture was cooled using ice brine to precipitate a white solid. After filtration, the filtrate was extracted with ethyl acetate. The organic phases were combined and washed twice with water, followed by drying the organic phase to acidity. After washing, 930 g of 6-(trifluoromethyl)-3-pyridinecarboxylic acid was obtained as a beige solid in 97.3% yield.

216431-85-5 Synthesis

216431-85-5
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$8.00/1g

231291-22-8
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$4.00/1g

Yield:231291-22-8 97.3%

Reaction Conditions:

with sulfuric acid;water;acetic acidReflux;

Steps:

5 Example 5

In a 10L three-necked flask was charged water 1420g, sulfuric acid 2440g, glacial acetic acid 150mL slowly added 6- (trifluoromethyl) nicotinonitrile 870g (5mol).Reflux overnight reaction.Cool, add ice and cool with ice-brine to precipitate a white solid.The filtrate was extracted with ethyl acetate. The organic phases were combined, washed twice with water and the organic phase was dried to dryness and acid-washed to give 930 g of 6-(trifluoromethyl)-3-picolinic acid as a beige solid. The yield was 97.3%.

References:

CN107298677,2017,A Location in patent:Paragraph 0036-0038

64-19-7 Synthesis