1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI) synthesis
- Product Name:1H-Pyrazole-3-carboxylicacid,4-amino-1-methyl-,methylester(9CI)
- CAS Number:637336-53-9
- Molecular formula:C6H9N3O2
- Molecular Weight:155.15
400877-57-8
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$15.00/250mg
637336-53-9
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$42.00/100mg
Yield: 100%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 20; for 4 h;
Steps:
70 Preparation 70: methyl 4-amino-1 -methyl-1 H-pyrazole-3-carboxylate
10% palladium/C (2.87 g, 2.7 mmol) was added to a stirred solution of methyl 1 -methyl- 4-nitro-1 H-pyrazole-3-carboxylate (p69, 7.15 g, 38.6 mmol) in methanol (250 ml_) and stirred at RT under H2 atmosphere for 4 hrs. The catalyst was filtered off and the solvent was evaporated under vacuum to afford methyl 4-amino-1 -methyl-1 H-pyrazole- 3-carboxylate (p70, 6 g, y= quant) as purple wax used as such in the next step. MS (/T7/z): 156.1 [MH]+
References:
CHRONOS THERAPEUTICS LIMITED;MICHELI, Fabrizio;CREMONESI, Susanna;SEMERARO, Teresa;TARSI, Luca;GIBSON, Karl Richard WO2019/81939, 2019, A1 Location in patent:Page/Page column 78
138786-86-4
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74-88-4
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$15.00/10g
637336-53-9
74 suppliers
$42.00/100mg
923283-54-9
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$65.00/100mg
138786-86-4
108 suppliers
$7.00/250mg
637336-53-9
74 suppliers
$42.00/100mg
4598-86-1
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$78.00/100mg
637336-53-9
74 suppliers
$42.00/100mg