Acetic acid, (cyclopropylamino)oxo-, ethyl ester (9CI) synthesis
- Product Name:Acetic acid, (cyclopropylamino)oxo-, ethyl ester (9CI)
- CAS Number:722486-66-0
- Molecular formula:C7H11NO3
- Molecular Weight:157.17
4755-77-5
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765-30-0
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722486-66-0
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Yield:722486-66-0 100%
Reaction Conditions:
with triethylamine in diethyl ether at 0 - 20; for 1 h;
Steps:
17.a
A solution of triethylamine (15.6 g, 154 mmol) and CYCLOPROPYLAMINE (4.85 ml, 70 mmol) in diethyl ether (50 ml) was added dropwise to a stirred solution of ethyloxalyl chloride (8.59 ml, 77 mmol) in diethyl ether (75 ml) at 0 °C. The reaction was allowed to warm to ambient temperature over 1 hour, was filtered and then concentrated in vacuo to yield ethyl (cyclopropylamino) (oxo) acetate as a brown oil which was used without further purification (12.5 g, quantitative yield): 'H-NMR (DMSO-d6): 8.85 (s, 1H), 4.20 (q, 2H), 2.70-2. 80 (M, 1H), 1.25 (t, 3H), 0.60-0. 70 (M, 2H), 0. 56 (M, 2H): MS (+ve ESI): 158 (M+H) +.
References:
WO2004/58782,2004,A1 Location in patent:Page 66-67
95-92-1
432 suppliers
$5.00/5G
765-30-0
501 suppliers
$10.00/25g
722486-66-0
24 suppliers
$65.00/50mg