5-isothiocyanato-3-(trifluoromethyl)picolinonitrile synthesis
- Product Name:5-isothiocyanato-3-(trifluoromethyl)picolinonitrile
- CAS Number:951753-87-0
- Molecular formula:C8H2F3N3S
- Molecular Weight:229.18
573762-62-6
239 suppliers
inquiry
463-71-8
154 suppliers
$29.89/5g
951753-87-0
100 suppliers
inquiry
Yield:951753-87-0 100%
Reaction Conditions:
in chloroform;N,N-dimethyl acetamide;water at 20; for 0.333333 h;
Steps:
7.A A. 5-isothiocyanato-3-(trifluoromethyl)picolinonitrile, 7b
To a solution of 5-amino-3-(trifluoromethyl)picolinonitrile (14.97 g, 80 mmol) inchloroform (150 mL) was added water (90 mL) and the mixture was stirred vigorously.DMA (10 mL) and thiophosgene (12.2 mL, 160 mmol) were then added dropwise. After20 mm, the layers were separated, the organic layer was dried over MgSO4, filtered andconcentrated to give 5-i sothiocyanato-3 -(trifluoromethyl)picolinonitrile (18.335 g, 100%) used directly into the next step.
References:
JANSSEN PHARMACEUTICA NV;BIGNAN, Gilles;CONNOLLY, Peter J.;HICKSON, Ian;MEERPOEL, Lieven;PANDE, Vineet;ZHANG, Zhuming;BRANCH, Jonathan;ROCABOY, Christian;TRABALON ESCOLAR, Luis B. WO2017/123542, 2017, A1 Location in patent:Page/Page column 224
573762-57-9
74 suppliers
inquiry
951753-87-0
100 suppliers
inquiry
22245-83-6
302 suppliers
$6.00/5g
951753-87-0
100 suppliers
inquiry
3796-23-4
227 suppliers
$7.00/1g
951753-87-0
100 suppliers
inquiry
22253-72-1
3 suppliers
inquiry
951753-87-0
100 suppliers
inquiry