Acetamide, N-(2-fluoro-4-methylphenyl)- synthesis
- Product Name:Acetamide, N-(2-fluoro-4-methylphenyl)-
- CAS Number:326-67-0
- Molecular formula:C9H10FNO
- Molecular Weight:167.18
452-80-2
75-36-5
326-67-0
To a solution of 2-fluoro-4-methylaniline (250 g, 2 mol) and triethylamine (202 g, 2 mol) dissolved in 2 L of dichloromethane, acetyl chloride (156 g, 2 mol) was added slowly and dropwise. The reaction mixture was stirred at 0 °C for 2 h and subsequently washed with dilute hydrochloric acid. The organic phase was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the crude intermediate N-(2-fluoro-4-methylphenyl)acetamide (334 g, 87% yield).
452-80-2
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$6.00/1g
108-24-7
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$14.00/250ML
326-67-0
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$22.00/100mg
Yield:326-67-0 97%
Reaction Conditions:
with triethylamine in dichloromethane at 0 - 20; for 3 h;
Steps:
3.1 Step 1: Preparation of N-(2-fluoro-4-methylphenyl)acetamide
Dissolve 2-fluoro-4methyl aniline (125g, 1mol) in dichloromethane (1L), add triethylamine (111g, 1.1mol), cool to internal temperature 0 degrees Celsius in an ice salt bath, slowly add acetic anhydride dropwise (102g, 1mol), after the addition is complete, the reaction solution is transferred to room temperature and the reaction is continued for 3 hours. Add 2L of water to the reaction solution, extract and separate the liquids, add anhydrous sodium sulfate to dry the organic phase and spin-evaporate to dryness to obtain white solid 162g , The yield is 97.0%.
References:
CN111825585,2020,A Location in patent:Paragraph 0165-0169
452-80-2
280 suppliers
$6.00/1g
75-36-5
588 suppliers
$17.92/100G
326-67-0
24 suppliers
$22.00/100mg
103-89-9
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$6.00/5g
326-67-0
24 suppliers
$22.00/100mg
352-70-5
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$14.00/5g
326-67-0
24 suppliers
$22.00/100mg
446-34-4
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$7.00/5g
108-24-7
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$14.00/250ML
326-67-0
24 suppliers
$22.00/100mg