天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Adapalene
106685-40-9

Adapalene synthesis

8synthesis methods
459423-32-6 Synthesis
3-(1-ADAMANTYL)-4-METHOXYBENZENEBORONIC ACID

459423-32-6
93 suppliers
$50.00/25mg

5773-80-8 Synthesis
6-Bromo-2-naphthoic acid

5773-80-8
310 suppliers
$10.00/1g

-

Yield:106685-40-9 99%

Reaction Conditions:

Stage #1: 3-(1-adamantyl)-4-methoxyphenylboronic acid;6-bromo-2-naphthoic acidwith potassium carbonate;palladium 10% on activated carbon in tetrahydrofuran;water; for 8 h;Heating / reflux;
Stage #2: with hydrogenchloride;water in tetrahydrofuran; for 1 h;Product distribution / selectivity;

Steps:

3

Example 3 :Preparation of 6- [3- (1-adamantyl) -4-methoxyphenyl] -2- naphthoic acid (I) :20 ml (12 vol) of tetrahydrofuran, 2 g (7 mmol) of 3-adamantyl-4-methoxyphenylboronic acid (II), 1.65 g (6.6 mmol) of 6 -broτno-2 -naphthoic acid (III) and 20 mL of a 2 M aqueous potassium carbonate solution are introduced into a round-bottomed flask equipped with EPO stirring and under a nitrogen stream. 0.7 g (5%) of 10% palladium on carbon (50% wet; Keraeus type K-0218) is then introduced.The medium is heated under reflux for 8 hours. The catalyst is filtered on a cartridge, and then slowly poured over 30 ml of a 1 N aqueous hydrochloric acid solution.The medium is kept stirring for one hour. The precipitate is filtered, washed with water and then dried under reduced pressure. 2.06 g of 6- [3- (1- adamantyl) -4-methoxyphenyl] -2-naphthoic acid are obtained in the form of a white solid whose purity, determined by HPLC, is 99.9% (yield = 79%; m.p. 321°C) .

References:

WO2006/108717,2006,A2 Location in patent:Page/Page column 11-12

Adapalene Related Search: