AKOS B013927 synthesis
- Product Name:AKOS B013927
- CAS Number:7472-69-7
- Molecular formula:C10H11BrO3
- Molecular Weight:259.1
106-41-2
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$13.00/5g
67-66-3
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$39.79/500ml
67-64-1
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$21.60/10ml
7472-69-7
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$57.50/250mg
Yield:7472-69-7 91%
Reaction Conditions:
Stage #1: 4-bromo-phenol;chloroform;acetonewith sodium hydroxide at 20 - 35; for 21.5 h;Heating / reflux;
Stage #2: with hydrogenchloride in water at 0;
Steps:
28.a
Finely crushed NaOH pellets (23.0 g, 576 mmol) were added in portions to 4-bromophenol (10.4 g, 60 mmol) in acetone (146 mL, 1980 mmol) keeping the temperature below 28°C. CHC13 (13 mL, 161 mmol) ) was added dropwise keeping the temperature below 35°C and the mixture was stirred at that temperature for 30 min, then at reflux for 3 h and at room temperature for 18 h. The mixture was then concentrated and the residue was diluted with water, cooled in an ice-bath and acidified with HCl (6M). The precipitate was allowed to settle and was collected by decantation. Water was added to the solid and the mixture was stirred vigorously for 5 min and then filtered. The solid was dried to give the -sub-title compound (14.0 g; 91%).
References:
WO2005/123673,2005,A1 Location in patent:Page/Page column 61
59227-80-4
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7472-69-7
36 suppliers
$57.50/250mg
106-41-2
505 suppliers
$13.00/5g
7472-69-7
36 suppliers
$57.50/250mg
106-41-2
505 suppliers
$13.00/5g
75-25-2
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67-64-1
0 suppliers
$21.60/10ml
7472-69-7
36 suppliers
$57.50/250mg