AKOS B019528 synthesis
- Product Name:AKOS B019528
- CAS Number:54384-71-3
- Molecular formula:C6H7N3
- Molecular Weight:121.14
25016-10-8
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Yield:54384-71-3 87%
Reaction Conditions:
with ammonium hydroxide;sodium bromate;acetic acid in water at 90 - 100; for 1 h;
Steps:
10 Synthesis of 1,5-dimethyl-1H-pyrazole-3-carbonitrile
in room temperature, Mix 1,5-dimethyl-1H-pyrazole-3-carbaldehyde (12.4 g, 0.1 mol), sodium bromate (7.5 g, 0.05 mol) and 200 g of acetic acid, add 50 g of ammonia-containing molecular mass concentration 25 % ammonia water and 400 ml water, heated to 90 ° C, the reaction is exothermic, maintain the reaction temperature at 100 ° C, reflux reaction for 1 hour to 1,5-dimethyl-1H-pyrazole-3-carbaldehyde complete reaction, cool to room temperature The reaction solution was poured into ice water to quench and dilute, neutralized until the reaction liquid was neutral, extracted with dichloromethane, dried, and concentrated, and then distilled under reduced pressure and recrystallized to obtain 10.5 g of product, yield 87%, purity. 98% or more.
References:
CN108707113,2018,A Location in patent:Paragraph 0036
54384-74-6
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5744-59-2
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$8.00/1g
54384-71-3
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