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ChemicalBook CAS DataBase List Benzocaine hydrochloride
23239-88-5

Benzocaine hydrochloride synthesis

5synthesis methods
Benzocaine hydrochloride is a topical anesthetic that works by blocking impulse propagation along nerve fibers and at nerve endings. P-nitrotoluene in sulfuric acid is oxidized with sodium dichromate to generate p-nitrobenzoic acid, which is esterified with ethanol.  The reaction is completed to give ethyl p-nitrobenzoate. Benzocaine is synthesized by iron powder was added ethyl p-nitrobenzoate in acetic acid with reducing reaction at 85～95℃.
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: bromine; acetic acid; triethylamine / 2 h / 20 °C
2: hydrogenchloride / ethyl acetate

References:

Takeda Pharmaceutical Company Limited EP1726580, 2006, A1

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