Dehydroepiandrosterone synthesis
- Product Name:Dehydroepiandrosterone
- CAS Number:53-43-0
- Molecular formula:C19H28O2
- Molecular Weight:288.43
853-23-6
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$28.00/5g
53-43-0
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Yield:53-43-0 94.8%
Reaction Conditions:
with methanol;sodium hydroxide at 40; for 4 h;Inert atmosphere;
Steps:
4.3
3 In a 100 mL single-mouth flask, 1.91 g of D-3 (5.8 mmol) obtained in Step 2 and 20 mL of anhydrous methanol were added, and stirred at room temperature for 15 min.Then 464 mg of solid sodium hydroxide (11.6 mmol) was added.Under the protection of nitrogen, the internal temperature was raised to 40 ° C for 4 h, and after TLC detected the reaction of the starting material, the reaction was stopped.Concentrate under reduced pressure to remove most of the solvent, then pour the concentrate into 200 mL of water and stir at room temperature for 1 h.Filter by suction and rinse with solid water (30mL×3).Drying gave 1.58 g of product D-4.An off-white solid with a molar yield of 94.8%.
References:
CN108864237,2018,A Location in patent:Paragraph 0051; 0056; 0057
63-05-8
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53-43-0
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571-36-8
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![10,13-dimethyl-17-oxo-3-sulfooxy-1,2,3,4,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene](/CAS/GIF/651-48-9.gif)
651-48-9
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53-43-0
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387-79-1
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53-43-0
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