ETHYL 2-(BROMOMETHYL)ACRYLATE synthesis
- Product Name:ETHYL 2-(BROMOMETHYL)ACRYLATE
- CAS Number:17435-72-2
- Molecular formula:C6H9BrO2
- Molecular Weight:193.04
105-53-3
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$5.00/25g
17435-72-2
200 suppliers
$9.00/1g
Yield:-
Reaction Conditions:
in acetonitrile
Steps:
P.1 [Formula (IA), X = COOCH2CH3; Y = R3 = R4 = H; R1 = R2 = CH2CH3].
Preparative Example 1 Ethyl 2,4-bis(ethoxycarbonyl)-4-pentenoate (Ia) [Formula (IA), X = COOCH2CH3; Y = R3 = R4 = H; R1 = R2 = CH2CH3]. [Typical procedure]. To a suspension of sodium hydride (80% dispersion in oil, 0.36g, 12mmol) in acetonitrile (10mL), was added diethyl malonate (1.60g, 10mmol). The resulting suspension was allowed to stir at room temperature for 15 minutes. A solution of ethyl α-(bromomethyl)acrylate [obtained from a modified procedure of S. E. Drewes, G. Loizou and G. H. P. Roos, Synthetic Communications, 1987, 17(3) , 291-298] (1.93g, 10mmol) in acetonitrile (5mL) was then added slowly to the above suspension. Stirring was maintained for 2 hours and then the reaction mixture was poured into water, and extracted (3x) with diethyl ether.
References:
COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION;E.I. du Pont de Nemours and Company (a Delaware corporation) EP729449, 2000, B1
10029-04-6
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17435-72-2
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64-17-5
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72707-66-5
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17435-72-2
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140-88-5
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$12.00/100ml
17435-72-2
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7789-60-8
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$10.40/25G
17435-72-2
200 suppliers
$9.00/1g