Fisetin synthesis
- Product Name:Fisetin
- CAS Number:528-48-3
- Molecular formula:C15H10O6
- Molecular Weight:286.24
58544-90-4
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528-48-3
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Yield:528-48-3 97%
Reaction Conditions:
with pyridine hydrochloride at 160; for 12 h;
Steps:
1 Production of 2-(3,4-dihydroxy-phenyl)-3,7-dihydroxy-chromen-4-one (fisetin, Formula 1)
Production of 2-(3,4-dihydroxy-phenyl)-3,7-dihydroxy-chromen-4-one (fisetin, Formula 1)
2-(3,4-dimethoxy-phenyl)-3-hydroxy-7-methoxy-chromen-4-one (17.0 g, 51.78 mmol) and pyridine hydrochloride (35.0 g) were added and stirred at 160° C. for 12 hours.
Water (600 mL) was added to the obtained solid mixture, followed by stirring at room temperature for 2 hours.
The resulting mixture was filtered to obtain fisetin (14.4 g, 97%) as a solid. 1H-NMR (400 MHz, DMSO) δ: 6.87 (3H, t, J=7.12 Hz), 7.51 (1H, dd, J=1.72, 1.68 Hz), 7.64 (1H, s), 7.89 (1H, d, J=9.32 Hz), 8.98 (1H, s), 9.21 (1H, s), 9.44 (1H, s), 10.68 (1H, s); HRMS (ES+) calculated for C15H10O6: 286.0477, found: 287.0544.
References:
US2022/220088,2022,A1 Location in patent:Paragraph 0071; 0073-0074
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60-18-4
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528-48-3
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