Irsogladine synthesis
- Product Name:Irsogladine
- CAS Number:57381-26-7
- Molecular formula:C9H7Cl2N5
- Molecular Weight:256.09
84504-69-8
57381-26-7
General procedure for the synthesis of 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine x maleate from 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine: 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine x maleate (0.3 g, 0.80 mmol) was dissolved in ethyl acetate ( 50 mL) and the reaction was stirred with saturated NaHCO3 solution (50 mL) for 1 hour at room temperature. After completion of the reaction, the organic layer was separated and washed with distilled water. The organic layer was dried over anhydrous Na2SO4 and concentrated under reduced pressure to afford the target product 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine in 70% yield.
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Yield: 70%
Reaction Conditions:
with sodium hydrogencarbonate in ethyl acetate at 20; for 1 h;
Steps:
Compound 8
Irsogladine Maleate (0.3g,0.80 mmol) was dissolved in ethyl acetate (50mL) and stirred with saturated NaHCO3 solution (50 mL) at room temperature for 1 hour. The organic layer was collected and washed with distilled water. The organic layer was further dried over Na2SO4 and concentrated under reduced pressure to afford compound 8 in 70% yield.
References:
Seo, Young Ho [Bulletin of the Korean Chemical Society,2015,vol. 36,# 5,p. 1495 - 1499] Location in patent:supporting information