METHYL 2-CHLORO-4-NITROBENZOATE synthesis
- Product Name:METHYL 2-CHLORO-4-NITROBENZOATE
- CAS Number:13324-11-3
- Molecular formula:C8H6ClNO4
- Molecular Weight:215.59
99-60-5
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$19.10/100g
74-88-4
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$15.00/10g
13324-11-3
120 suppliers
$14.00/1g
Yield:13324-11-3 92%
Reaction Conditions:
with 1,8-diazabicyclo[5.4.0]undec-7-ene in acetonitrile at 20; for 1.5 h;
Steps:
Synthesis of 7a
A mixture of 6a (10.0 g, 49.6 mmol), 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU, 15.0 mL, 100 mmol), and iodomethane (7.8 mL, 0.13 mol) in dry acetonitrile (82 mL) was stirred at room temperature for 1.5 h and concentrated under reduced pressure. Water and ethyl acetate were added, and the mixture was extracted with ethyl acetate. The organic layer was washed with 1 mol/L hydrochloric acid and brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. Purification with silica gel column chromatography (hexane/ethyl acetate = 6/1) afforded 7a (9.81g, 92%) as a pale yellow solid.
References:
Yokoyama, Akihiro;Ishii, Arisa;Ohishi, Tomoyuki;Kikkawa, Shoko;Azumaya, Isao [Tetrahedron Letters,2021,vol. 62,art. no. 152704] Location in patent:supporting information
99-60-5
335 suppliers
$19.10/100g
77-78-1
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$19.69/1ml
13324-11-3
120 suppliers
$14.00/1g
67-56-1
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$7.29/5ml-f
99-60-5
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$19.10/100g
13324-11-3
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$14.00/1g
619-50-1
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$17.00/25g
13324-11-3
120 suppliers
$14.00/1g
75-91-2
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$26.00/100g
99-60-5
335 suppliers
$19.10/100g
13324-11-3
120 suppliers
$14.00/1g