Methyl 3-hydroxypropanoate synthesis
- Product Name:Methyl 3-hydroxypropanoate
- CAS Number:6149-41-3
- Molecular formula:C4H8O3
- Molecular Weight:104.1
67-56-1
780 suppliers
$7.29/5ml-f
57-57-8
169 suppliers
$24.73/250mgs:
6149-41-3
152 suppliers
$20.00/1g
Yield:6149-41-3 97%
Reaction Conditions:
with sulfuric acid at 0; for 18 h;
Steps:
52 Preparation of methyl 3-hydroxypropanoate
Oxetan-2-one (22 mL, 350 mmol) was added dropwise to a stirred solution of MeOH (300 mL) and sulfuric acid (5.6 mL, 104 mmol) at 0° C. After 18 h, the reaction was recooled to 10° C., and sodium bicarbonate (18.1 g, 215 mmol) was added portionwise (pH=7 after addition). The resulting suspension was left to stir at r.t. for 30 minutes. The mixture was then filtered, and the filtrate was concentrated under reduced pressure. The resulting residue was diluted with DCM and filtered a second time. The new filtrate was evaporated to dryness to afford methyl 3-hydroxypropanoate (35 g, 97%) as a colorless liquid. 1H NMR (500 MHz, CDCl3, 24° C.) 2.41-2.45 (1H, m), 2.58 (2H, t), 3.72 (3H, s), 3.89 (2H, t).
References:
AstraZeneca AB;Barlaam, Bernard;De Savi, Christopher;Hawkins, Janet;Hird, Alexander;Lamb, Michelle;Pike, Kurt;Vasbinder, Melissa US2016/376287, 2016, A1 Location in patent:Paragraph 1004
67-56-1
780 suppliers
$7.29/5ml-f
109-78-4
384 suppliers
$10.00/1g
6149-41-3
152 suppliers
$20.00/1g
57-57-8
169 suppliers
$24.73/250mgs:
6149-41-3
152 suppliers
$20.00/1g
1221443-23-7
12 suppliers
inquiry
75-21-8
239 suppliers
$33.29/crm44609
67-56-1
780 suppliers
$7.29/5ml-f
143-24-8
369 suppliers
$11.00/100g
201230-82-2
1 suppliers
inquiry
6149-41-3
152 suppliers
$20.00/1g
75-21-8
239 suppliers
$33.29/crm44609
67-56-1
780 suppliers
$7.29/5ml-f
201230-82-2
1 suppliers
inquiry
6149-41-3
152 suppliers
$20.00/1g