METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE synthesis
- Product Name:METHYL 5-BROMO-1H-INDAZOLE-3-CARBOXYLATE
- CAS Number:78155-74-5
- Molecular formula:C9H7BrN2O2
- Molecular Weight:255.07
1077-94-7
186 suppliers
$11.00/250mg
67-56-1
776 suppliers
$9.00/25ml
78155-74-5
115 suppliers
$9.00/100mg
Yield:78155-74-5 98%
Reaction Conditions:
with sulfuric acid for 4 h;Reflux;Inert atmosphere;
Steps:
25.2 Step 2
Concentrated sulfuric acid (1 mL) was added to a suspension of 5- bromo-lH-indazole-3-carboxylic acid (CXV) (1.30 g, 5.39 mmol) in dry MeOH (50 mL) and heated to reflux for 4 h under argon. The solution was cooled to room temperature and the MeOH was evaporated under vacuum. The residue was dissolved in EtOAc and washed with water. The organic phase was dried over Na2S04, filtered and concentrated to afford methyl 5-bromo-lH-indazole-3-carboxylate (CXVI) as a white solid (1.35 g, 5.29 mmol, 98% yield). 1H NMR (DMSO-d6) δ ppm 14.13 (s, 1H), 8.21 (d, J = 1.6 Hz, 1H), 7.67 (d, J= 7.2 Hz, 1H), 7.59 (dd, J= 7.2, 1.2 Hz, 1H), 3.92 (s, 3H); ESIMS found for C9H7BrN202 mlz 256.0 (M+H).
References:
WO2013/40215,2013,A1 Location in patent:Paragraph 00340
43120-28-1
171 suppliers
$10.00/1g
78155-74-5
115 suppliers
$9.00/100mg
67-56-1
776 suppliers
$9.00/25ml
201230-82-2
1 suppliers
inquiry
459133-66-5
157 suppliers
$10.00/250mg
78155-74-5
115 suppliers
$9.00/100mg
4498-67-3
492 suppliers
$6.00/5g
78155-74-5
115 suppliers
$9.00/100mg
87-48-9
293 suppliers
$10.00/5g
78155-74-5
115 suppliers
$9.00/100mg