Methyl isonicotinate synthesis
- Product Name:Methyl isonicotinate
- CAS Number:2459-09-8
- Molecular formula:C7H7NO2
- Molecular Weight:137.14
Yield:2459-09-8 80%
Reaction Conditions:
with sulfuric acidReflux;
Steps:
1.1 (1) Synthesis of isonicotinic acid methyl ester of formula (II)
Isonicotinic acid (0.1 mol), sulfuric acid (0.12 mol) and anhydrous methanol (0.12 mol), was added to a 150 ml single-necked flask, the reaction was heated to reflux, after the end of the reaction, spin off the solvent, washed with water to prepare 12.08 g of isonicotinate as shown in formula (II), Yield 80%.
References:
Zhejiang University of Technology;Liu Xinghai;Zhao Wen;Zhai Zhiwen;Sun Zhaohui;Weng Jianquan;Tan Chengxia;Liu Xufeng;Ding Xiaomin CN106699776, 2017, A Location in patent:Paragraph 0024-0025; 0027-0029
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