N-Acetyl carnosine synthesis
- Product Name:N-Acetyl carnosine
- CAS Number:56353-15-2
- Molecular formula:C11H16N4O4
- Molecular Weight:268.27
3025-95-4
71-00-1
56353-15-2
In a 500 mL three-necked flask, 300 mL of anhydrous ethanol was added and 80 g (0.611 mol) of N-acetyl-β-alanine and 86.1 g (0.555 mol) of L-histidine were sequentially added followed by 98 g (0.582 mol) of N,N'-dimethylcarbodiimide (DMC). The reaction mixture was heated to 40°C and the reaction was kept stirring for 3 hours. Upon completion of the reaction, the reaction solution was cooled to 5°C, a solid was precipitated and the solid product was collected by filtration. The filter cake was washed with 150 mL of anhydrous ethanol and dried under vacuum to give 145 g of (S)-2-(3-acetamidopropionamide)-3-(1H-imidazol-4-yl)propanoic acid (IV) in 97.9% yield and >98.8% HPLC purity.
3025-95-4
153 suppliers
$5.00/1g
71-00-1
806 suppliers
$7.00/5g
56353-15-2
319 suppliers
$11.00/250mg
Yield:56353-15-2 97.9%
Reaction Conditions:
with 2-chloro-1,3-dimethylimidazolinium chloride in ethanol at 40; for 3 h;Concentration;Reagent/catalyst;Solvent;Temperature;
Steps:
17 preparation of N-acetyl-L-carnosine crude(IV)
In a 500 mL reaction flask,Add anhydrous ethanol 300mL,80 g of N-acetyl-β-alanine (0.611 mol)86.1 g L-histidine (0.555 mol),98 g of DMC (0.582 mol),Heating up to 40 ,Reaction for 3 hours,Cooling to 5 ,Filter,The filter cake was rinsed with 150 mL of anhydrous ethanol,Solid-dried product (IV) 145g,The yield was 97.9%HPLC purity> 98.8%.
References:
CN105461632,2016,A Location in patent:Paragraph 0046
3025-95-4
153 suppliers
$5.00/1g
56353-15-2
319 suppliers
$11.00/250mg
71-00-1
806 suppliers
$7.00/5g
56353-15-2
319 suppliers
$11.00/250mg