N-Cyclopropyl 4-chloropicolinaMide synthesis
- Product Name:N-Cyclopropyl 4-chloropicolinaMide
- CAS Number:1090815-16-9
- Molecular formula:C9H9ClN2O
- Molecular Weight:196.63
24484-93-3
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765-30-0
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1090815-16-9
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Yield:1090815-16-9 90.1%
Reaction Conditions:
in tetrahydrofuran;methanol at 2 - 20;
Steps:
5.3.2. 4-Chloro-N-methylpicolinamide (4a)11
General procedure: The compound 3 (10 g, 58.3 mmol) was dissolved in 70 mL methanol/THF (2/5) mixture at 0 °C, then a solution of methylamine (5 g, 161.3 mmol) in THF (60 mL) was added at a rate that kept the internal temperature below 2 °C. The mixture was stirred at room temperature for 3 h and then was concentrated in vacuo. The crude product was dissolved in 100 mL ethyl acetate and was washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 4a (9.4 g, 94.5%) as light yellow crystalline.
References:
Yao, Jianwen;Chen, Jing;He, Zuopeng;Sun, Wei;Xu, Wenfang [Bioorganic and Medicinal Chemistry,2012,vol. 20,# 9,p. 2923 - 2929] Location in patent:experimental part
98-98-6
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765-30-0
502 suppliers
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1090815-16-9
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$45.00/50mg
5470-22-4
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765-30-0
502 suppliers
$10.00/25g
1090815-16-9
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$45.00/50mg
53750-66-6
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$60.00/250mg
765-30-0
502 suppliers
$10.00/25g
1090815-16-9
14 suppliers
$45.00/50mg
98-98-6
637 suppliers
$5.00/10g
1090815-16-9
14 suppliers
$45.00/50mg