N-ETHYLGLYCINE synthesis
- Product Name:N-ETHYLGLYCINE
- CAS Number:627-01-0
- Molecular formula:C4H9NO2
- Molecular Weight:103.12
298-12-4
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Yield:-
Reaction Conditions:
with hydrogen in isopropyl alcohol
Steps:
5 Preparation of N-ethylglycine.
EXAMPLE 5 Preparation of N-ethylglycine. To a 5° C. mixture under nitrogen of ethylamine (25 kg) and isopropanol (100 kg) in a 250 liter glass lined reactor is added a solution of glyoxylic acid (25 kg) in isopropanol (25 kg) over 2-3 hours and the solution is hydrogenated with palladium on charcoal (50% wet, 5%, 2.5 kg) over 3 hours under 50 mbar of hydrogen. The reaction mixture is then filtered and the filtrate is concentrated. Isopropanol (80 kg) is added to the slurry and the solid is filtered, washed twice with isopropanol (7 kg), and dried in vacuo at about 40° C. to give N-ethylglycine (21 kg) as a white crystalline solid.
References:
Aventis Pharmaceuticals Products Inc. US6180759, 2001, B2
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$45.00/100mg
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627-01-0
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627-01-0
79 suppliers
$45.00/100mg