nooglutil synthesis
- Product Name:nooglutil
- CAS Number:112193-35-8
- Molecular formula:C11H12N2O6
- Molecular Weight:268.22
A solution of 233 g (5.83 mol) of NaOH in 930 mL of water was added to 345 g of the raw diethyl ester 15 ina 3-L one-neck flask, and the mixture was stirred a troom temperature for 2 h, after which 30 g of activated carbon was added, and stirring was continued for an additional 30 min and filtered on a Buchner funnel tor remove the activated carbon. The filtrate was made acidic (pH 4) by adding 545 mL of conc. HCl and stirred for 1 h. The precipitate was filtered off (Schott filter no. 3), washed with water (3 × 600 mL), suspended in 750 mL of water, acidified to pH 4 with 65 mL of conc. HCl, and immediately neutralized to pH 8 with 90 mL of 40% NaOH. Activated carbon, 13 g, was then added, and the mixture was stirred for 30 min, the activated carbon was removed by filtration, and the filtrate was acidified to pH 4 with conc. HCl. The precipitate was filtered off, washed with water (3 × 500 mL), and dried at 55 °C and a vacuum of 40 mmHg for 12 h to obtain 129 g (70%) of the target product, purity by HPLC 99.61%, main substance content by titration 80% (water 21%).
112193-39-2
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Yield:-
Steps:
Multi-step reaction with 2 steps
1: 97 percent / conc. HCl, NaNO2 / H2O / 0.5 h / 0 °C
2: 68 percent / 1 N NaOH / 0.5 h / 20 °C / pH 9-9.5
References:
Kuznetsova;Voronina;Khromova;Garibova;Tosina;Stolyarova;Troitskaya;Smirnov [Pharmaceutical Chemistry Journal,1990,vol. 23,# 12,p. 943 - 949]
59288-38-9
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$20.00/1g
112193-35-8
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27828-71-3
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$6.00/5g
112193-35-8
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