PIVALAMIDE synthesis
- Product Name:PIVALAMIDE
- CAS Number:754-10-9
- Molecular formula:C5H11NO
- Molecular Weight:101.15
3282-30-2
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3863-11-4
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$10.00/25 g
754-10-9
174 suppliers
$7.00/5g
Yield:-
Reaction Conditions:
with triethylamine in dichloromethane
Steps:
13.A Part A:
Part A: Preparation of N-trimethylacetyl-3,4-difluoroandlide. To a solution of 3,4-difluoroaniline (19 mL, 191 mmol) in methylene chloride (500 mL) at 0° was added triethylamine (32 mL, 230 mmol) followed dropwise with trimethylacetyl chloride (24 mL, 191 mmol) and the resulting reaction mixture was allowed to stir at room temperature for 3 h. The reaction mixture was poured onto 3N HCl ard extracted with methylene chloride (3*100 mL) and the combined organic extracts were dried over anhydrous NaSO4 and concentrated in vacuo. The residue was taken up in hexanes (300 mL) and filtered through a sintered glass funnel. The solids are washed thoroughly with hexanes (500 mL) and dried under vacuum to give 37.36 g of the pivaloyl amide as a solic (40.68 g theoretical, 92% yield).
References:
Dupont Pharmaceuticals Company US6140320, 2000, A
75-98-9
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754-10-9
174 suppliers
$7.00/5g
630-18-2
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$10.00/1g
754-10-9
174 suppliers
$7.00/5g
3282-30-2
370 suppliers
$18.00/100ml
754-10-9
174 suppliers
$7.00/5g