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ChemicalBook CAS DataBase List (R)-1-Boc-3-methylpiperazine
163765-44-4

(R)-1-Boc-3-methylpiperazine synthesis

3synthesis methods
To a solution of (R)-methylpiperazine (400 mg) in dichloromethane (20 mL) at 0 ℃ was added di-tert-butyl dicarbonate (871 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL), followed by extraction into dichloromethane (2 x 40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4), and concentrated to give (R)-1-Boc-3-methylpiperazine as a white solid (669 mg, 84%).

(R)-4-Boc-2-methylpiperazine
24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
863 suppliers
$13.50/25G

75336-86-6 Synthesis
(R)-(-)-2-Methylpiperazine

75336-86-6
242 suppliers
$9.00/5g

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Yield:163765-44-4 84%

Reaction Conditions:

in dichloromethane at 0 - 20; for 4 h;

Steps:

195
To a solution of (R)-methylpiperazine (400 mg) in dichloromethane (20 mL) at 0 0C was added di-tert-butyl dicarbonate (871 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL) and extracted into dichloromethane (2 x 40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4) and concentrated to give (R)-3-methyl-piperazine-l- carboxylic acid tert-butyl ester as a white solid (669 mg, 84%).

References:

PIRAMED LIMITED;GENENTECH, INC.;BAYLISS, Tracy;CHUCKOWREE, Irina;FOLKES, Adrian;OXENFORD, Sally;WAN, Nan, Chi;CASTANEDO, Georgette;GOLDSMITH, Richard;GUNZNER, Janet;HEFFRON, Tim;MATHIEU, Simon;OLIVERO, Alan;STABEN, Steven;SUTHERLIN, Daniel, P.;ZHU, Bing-Yan WO2008/70740, 2008, A1 Location in patent:Page/Page column 191

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