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ChemicalBook CAS DataBase List Ramatroban
116649-85-5

Ramatroban synthesis

6synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 10 steps
1.1: magnesium sulfate / dichloromethane / 2 h / 20 °C
1.2: 4 h / 110 °C
2.1: trifluoroacetic acid / acetone / 24 h / 65 °C
3.1: sodium tetrahydroborate / methanol / 1.5 h / 0 - 20 °C / Inert atmosphere
4.1: Candida antarctica Lipase A / tetrahydrofuran / 5 h / 30 °C / Enzymatic reaction
5.1: dmap; triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere
6.1: sodium azide / N,N-dimethyl-formamide / 24 h / 70 °C
7.1: water; triphenylphosphine / 15 h / 65 °C
8.1: triethylamine / dichloromethane / 1 h / 20 °C
9.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 20 °C
9.2: 1 h / 20 °C
10.1: water; sodium hydroxide / isopropyl alcohol / 24 h / 100 °C

References:

Busto, Eduardo;Gotor-Fernandez, Vicente;Gotor, Vicente [Journal of Organic Chemistry,2012,vol. 77,# 10,p. 4842 - 4848]

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