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153562-66-4

RARECHEM AL BI 1228 synthesis

5synthesis methods
-

Yield:153562-66-4 77%

Reaction Conditions:

Stage #1: 2-acetyl-3-chlorothiophenewith pyridine;iodine;copper(II) oxide in ethanol; for 16 h;Reflux;
Stage #2: ethanolwith potassium carbonate for 2 h;Reflux;

References:

Fang, Zhanxiong;Liao, Pei-Chun;Yang, Yu-Liang;Yang, Feng-Ling;Chen, Yi-Lin;Lam, Yulin;Hua, Kuo-Feng;Wu, Shih-Hsiung [Journal of Medicinal Chemistry,2010,vol. 53,# 22,p. 7967 - 7978] Location in patent:supporting information; experimental part