Rabeprazole Sodium synthesis
- Product Name:Rabeprazole Sodium
- CAS Number:117976-90-6
- Molecular formula:C18H21N3O3S.Na
- Molecular Weight:382.43
117976-89-3
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$15.00/1mg
117976-90-6
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$25.00/5mg
Yield:117976-90-6 100%
Reaction Conditions:
with sodium hydroxide in ethanolProduct distribution / selectivity;
Steps:
2; 3
Example 2 Ethanol (30 ml) was added to sodium hydroxide (2.25 g (55.1 mmol)), and dissolution was carried out. 2-[{4-(3-Methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole (20.0 g (55.6 mmol)) was then put into the ethanol solution, and after dissolution had been confirmed, diisopropyl ether (2000 ml) was added slowly, whereby 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole sodium salt (22.8 g) was obtained through precipitation (yield 100%).; Example 3 Ethanol (22.5 ml) was added to sodium hydroxide (1.65 g (41.3 mmol)), and dissolution was carried out. 2-[{4-(3-Methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole (15.0 g (41.7 mmol)) was then put into the ethanol solution, and after dissolution had been confirmed, tert-butyl methyl ether (160 ml) was added slowly, whereby 2-[{4-(3-methoxypropoxy)-3-methylpyridin-2-yl}methylsulfinyl]-1H-benzimidazole sodium salt (15.9 g) was obtained through precipitation (yield 100%).
References:
Urawa, Yoshio US2007/225502, 2007, A1 Location in patent:Page/Page column 5
![2-{[4-(3-Methoxypropoxy)-3-methylpyridine-2-yl]methylthio}-1H-benzimidazole](/CAS/GIF/117977-21-6.gif)
117977-21-6
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$8.00/5g
117976-90-6
641 suppliers
$25.00/5mg
1310-73-2
1403 suppliers
$14.00/25g
117977-21-6
354 suppliers
$8.00/5g
117976-90-6
641 suppliers
$25.00/5mg
1310-73-2
1403 suppliers
$14.00/25g
117976-89-3
248 suppliers
$15.00/1mg
117976-90-6
641 suppliers
$25.00/5mg
117977-20-5
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117976-90-6
641 suppliers
$25.00/5mg