Yield:327051-11-6 97.5%

Reaction Conditions:

with hydrogenchloride in ethyl acetate at 20; for 2 h;

Steps:

2.2.2 (2) L-O-methyl serine methyl ester hydrochloride (IIIe) preparation of

IIIe-1 the compound (496 mg, 2 . 1mmol) dissolved in ethyl acetate (2.5 ml) in, the ice-bath next adds by drops ethyl acetate solution of HCl (5.2 ml, 21 . 2mmol), reaction at room temperature, TLC detection reaction, 2h end of the reaction, filtration, the filter cake vacuum drying to obtain the pure product 351 mg, yield 97.5%.

References:

CN105732683,2016,A Location in patent:Paragraph 0131; 0132; 0135; 0136