天堂网亚洲,天天操天天搞,91视频高清,菠萝蜜视频在线观看入口,美女视频性感美女视频,95丝袜美女视频国产,超高清美女视频图片

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List Thiazole, 2,5-dibromo-4-chloro-
57314-10-0

Thiazole, 2,5-dibromo-4-chloro- synthesis

1synthesis methods
-

Yield:-

Reaction Conditions:

with bromine;acetic acid at 60 - 90; for 5.5 h;

Steps:

1

2,4-Dichlorothiazole (10 g, 64.9 mmol) was dissolved in acetic acid (50.0 ml) and heated to 60° C. Bromine (15.05 ml, 292 mmol) was added dropwise and the reaction mixture stirred at 90° C. for 5.5 hours. The mixture was cooled to room temperature and made basic by slow addition of solid sodium carbonate, then diluted with water (100 mL) and extracted with Et2O (3×150 ml). The combined organic extracts were washed with sat. aq. sodium thiosulfate (50 ml) dried over sodium sulfate evaporated under reduced pressure to afford the title compound as a pale yellow oil. [1895] LC-MS Rt 1.43 min [M+H]+ 275.9/277.9/279.9/281.9 (Method 2minLowpHv03)

References:

US2014/171417,2014,A1 Location in patent:Paragraph 1894; 1895