| Identification | More | [Name]
2-Bromo-4-fluoroaniline | [CAS]
1003-98-1 | [Synonyms]
2-BROMO-4-FLUOROANILINE
2-BROMO-4-FLUORO-PHENYLAMINE
4-FLUORO-2-BROMOANILINE
Bromofluoroaniline1
2-Bromo-4-fluoroaniline 99%
2-Bromo-4-fluoroaniline99%
2-BROMO-4-FLUOROANILINE 98+%
Benzenamine, 2-bromo-4-fluoro- | [EINECS(EC#)]
619-469-3 | [Molecular Formula]
C6H5BrFN | [MDL Number]
MFCD00042462 | [Molecular Weight]
190.01 | [MOL File]
1003-98-1.mol |
| Chemical Properties | Back Directory | [Appearance]
Clear yellow-brown liquid | [Melting point ]
41 | [Boiling point ]
221 °C (lit.) | [density ]
1.67 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.583(lit.)
| [Fp ]
220 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [form ]
Liquid | [pka]
2.60±0.10(Predicted) | [color ]
Clear yellow-brown | [Specific Gravity]
1.670 | [BRN ]
2802562 | [InChI]
InChI=1S/C6H5BrFN/c7-5-3-4(8)1-2-6(5)9/h1-3H,9H2 | [InChIKey]
YLMFXCIATJJKQL-UHFFFAOYSA-N | [SMILES]
C1(N)=CC=C(F)C=C1Br | [CAS DataBase Reference]
1003-98-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi,T | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [RIDADR ]
UN2810 | [WGK Germany ]
3
| [Hazard Note ]
Toxic | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29214200 |
| Hazard Information | Back Directory | [Uses]
2-Bromo-4-fluoroaniline is an organic compound that is an aniline derivative. It is mainly used as an organic synthesis reagent in experimental research. | [Chemical Properties]
Clear yellow-brown liquid | [General Description]
2-Bromo-4-fluoroaniline is an aryl fluorinated building block. | [Synthesis]
The general procedure for the synthesis of 2-bromo-4-fluoroaniline from 4-fluoroaniline was as follows: 200 mL of distilled N,N-dimethylformamide (DMF) and 4-fluoroaniline (8.64 mL, 58.13 mmol) were added to a two-necked flask equipped with a stirring device. N-bromosuccinimide (11.4 g, 63.95 mmol) dissolved in DMF was added slowly and dropwise with stirring. After completion of the reaction, extraction was carried out using dichloromethane (CH2Cl2). The product was purified by column chromatography (eluent ratio of ethyl acetate: n-hexane = 1:4), and the target product 2-bromo-4-fluoroaniline was finally obtained in 95% yield. | [References]
[1] Patent: KR2018/50795, 2018, A. Location in patent: Paragraph 0134; 0135; 0152-0154
[2] Tetrahedron Letters, 2000, vol. 41, # 13, p. 2083 - 2085
[3] Journal of the American Chemical Society, 2011, vol. 133, # 18, p. 6868 - 6870
[4] Chemistry - A European Journal, 2011, vol. 17, # 49, p. 13665 - 13669
[5] Tetrahedron Letters, 2014, vol. 55, # 38, p. 5338 - 5341 |
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