| Identification | More | [Name]
5-AMINO-1-N-METHYLINDOLE | [CAS]
102308-97-4 | [Synonyms]
1-METHYL-1H-INDOL-5-AMINE
1-METHYL-1H-INDOL-5-YLAMINE
1-METHYL-1H-INDOLE-5-YLAMINE
5-AMINO-1-N-METHYLINDOLE
5-AMINO-N-METHYLINDOLE
TIMTEC-BB SBB010309
5-Amino-1-methyl-1H-indole 97%
1H-Indol-5-amine,1-methyl-(9CI)
5-AMINO-1-N-METHYLINDOLE 97%
5-Amino-1-methyl-1H-indole | [Molecular Formula]
C9H10N2 | [MDL Number]
MFCD03839873 | [Molecular Weight]
146.19 | [MOL File]
102308-97-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
102 °C | [Boiling point ]
143-144 °C(Press: 2 Torr) | [density ]
1.15±0.1 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
Acetonitrile (Slightly), Chloroform (Slightly) | [form ]
Solid | [pka]
5.05±0.10(Predicted) | [color ]
Black | [CAS DataBase Reference]
102308-97-4(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [RIDADR ]
2811 | [HazardClass ]
IRRITANT | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Brown solid | [Uses]
5-Amino-1-N-methylindole (CAS# 102308-97-4) is an indole derivative and building block, used in the copper-catalyzed synthesis of sulfonamides. | [Synthesis]
The general procedure for the synthesis of 1-methyl-5-aminoindole using 1-methyl-5-nitroindole as starting material was as follows: 10% Pd/C catalyst (0.18 g/g by mass of the feedstock) was added to the feedstock solution (THF dosage of 54 mL/g of feedstock) dissolved in THF. The reaction flask was sealed and air was removed by vacuum. Subsequently, a hydrogen-filled balloon was attached to the flask. The reaction was stirred continuously at room temperature for 24 to 48 hours or monitored by TLC until the feedstock completely disappeared. Upon completion of the reaction, the mixture was filtered through diatomaceous earth. The filtrate was collected and the solvent was removed by rotary evaporation to give a brown solid product in 100% yield. The structure of the product was confirmed by 1H NMR (DMSO-d6) and 13C NMR (DMSO-d6): 1H NMR (DMSO-d6): δ 7.15-7.05 (m, 2H), 6.71 (dd, J = 3.0, 0.9 Hz, 1H), 6.57 (dd, J = 8.5, 2.1 Hz, 1H), 6.12 (dd, J = 3.0, 0.9 Hz, 1H), 3.67 (s, 3H); 13C NMR (DMSO-d6): δ 141.30, 131.12, 129.49, 129.44, 129.41, 112.31, 110.11, 104.21, 99.13, 32.86. | [References]
[1] European Journal of Medicinal Chemistry, 2018, vol. 157, p. 1202 - 1213
[2] Bioorganic and Medicinal Chemistry, 2005, vol. 13, # 10, p. 3531 - 3541
[3] New Journal of Chemistry, 2015, vol. 39, # 7, p. 5360 - 5365
[4] Patent: CN104163815, 2017, B. Location in patent: Paragraph 0065; 0066; 0068
[5] Patent: CN107163029, 2017, A. Location in patent: Paragraph 0049; 0053; 0054; 0055; 0056; 0057; 0058 |
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