| Identification | More | [Name]
2,3-Dihydro-1-benzofuran-5-sulfonyl chloride | [CAS]
115010-11-2 | [Synonyms]
2,3-DIHYDRO-1-BENZOFURAN-5-SULFONOYL CHLORIDE
2,3-DIHYDRO-1-BENZOFURAN-5-SULFONYL CHLORIDE
2,3-DIHYDRO-1-BENZOFURAN-5-SULPHONYL CHLORIDE
2,3-DIHYDROBENZO[B]FURAN-5-SULFONYL CHLORIDE
2,3-DIHYDROBENZO[B]FURAN-5-SULPHONYL CHLORIDE
AKOS MSC-0778
BUTTPARK 37\04-17
2,3-dihydrobenzofuran-5-sulfonyl chloride
2,3-Dihydro-1-benzofurane-5-sulfonylchloride
2,3-Dihydrobenzofuranyl-5-Sulfonyl Chloride
5-Benzofuransulfonylchloride,2,3-dihydro-(9CI)
2,3-dihydro-5-Benzofuransulfonyl chloride | [Molecular Formula]
C8H7ClO3S | [MDL Number]
MFCD02677703 | [Molecular Weight]
218.66 | [MOL File]
115010-11-2.mol |
| Questions And Answer | Back Directory | [Synthesis]
Under argon protection, 3.56 g (29.6 mmol) of 2,3-dihydrobenzofuran was added to a 12 mL slurry of 1,2-dichloroethane containing 5.44 g (35.5 mmol) of sulfur trioxide-N,N-dimethylformamide complex. The reaction system was heated to 85 °C, maintained for 1 h and cooled to room temperature. Subsequently, thionyl chloride (2.6 mL, 35.5 mmol, 1.2 eq.) was added slowly and the temperature was gradually increased to 75 °C over 1 hour. After completion of the reaction, the mixture was cooled to room temperature and extracted by adding 100 mL of dichloromethane and 100 mL of water. The organic phase was separated, dried with anhydrous magnesium sulfate, filtered and concentrated under reduced pressure to give 6.56 g (100% yield) of 2,3-dihydrobenzofuran-5-sulfonyl chloride as a tan oil (TLC Rf value, chloroform/hexane=1/1). references: [1] Patent: US2005/267074, 2005, A1. Location in patent: Page/Page column 25; 44 [2] Patent: US2008/227744, 2008, A1. Location in patent: Page/Page column 12-13 [3] Patent: US6506754, 2003, B1 [4] Patent: US5387681, 1995, A [5] Patent: WO2005/58858, 2005, A1. Location in patent: Page/Page column 129 |
| Safety Data | Back Directory | [Hazard Codes ]
C | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) . | [RIDADR ]
3261 | [Hazard Note ]
Corrosive | [HazardClass ]
8 | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅲ |
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