| Identification | More | [Name]
3-Amino-4-chlorobenzotrifluoride | [CAS]
121-50-6 | [Synonyms]
2-CHLORO-5-(TRIFLUOROMETHYL)ANILINE
3-AMINO-4-CHLORO-A,A,A-TRIFLUOROTOLUENE
3-AMINO-4-CHLOROBENZOTRIFLUORIDE
3-AMINO-4-CHLOROTRIFLUOROTOLUENE
4-CHLORO-3-AMINOBENZOTRIFLUORIDE
4-CHLORO-A,A,A-TRIFLUORO-M-TOLUIDINE
6-CHLORO-A,A,A-TRIFLUORO-M-TOLUIDINE
6-CHLORO-ALPHA,ALPHA,ALPHA-TRIFLUORO-M-TOLUIDINE
AKOS BBS-00000946
C.I. 37050
FAST ORANGE RD OIL
LABOTEST-BB LT00053884
TIMTEC-BB SBB003593
2-chloro-5-(trifluoromethyl)-benzenamin
3-Amino-4-chloro-alpha,alpha,alpha-trifluorotoluene
6-Chloro-3-(trifluoromethyl)aniline
6-chloro-alpha,alpha,alpha-trifluoro-m-toluidin
Azoene Fast Orange RD Salt
azoenefastorangerdsalt
Benzenamine,2-chloro-5-(trifluoromethyl)- | [EINECS(EC#)]
204-475-7 | [Molecular Formula]
C7H5ClF3N | [MDL Number]
MFCD00007673 | [Molecular Weight]
195.57 | [MOL File]
121-50-6.mol |
| Chemical Properties | Back Directory | [Appearance]
CLEAR COLORLESS TO LIGHT YELLOW LIQUID | [Melting point ]
10 °C | [Boiling point ]
82-83 °C (9 mmHg) | [density ]
1.428 g/mL at 25 °C(lit.)
| [vapor pressure ]
0.15 hPa | [refractive index ]
n20/D 1.499(lit.)
| [Fp ]
75 °C
| [storage temp. ]
Store below +30°C. | [solubility ]
11g/l | [Colour Index ]
37050 | [form ]
clear liquid | [pka]
1.43±0.10(Predicted) | [color ]
Colorless to Yellow to Green | [Specific Gravity]
1.428 | [Water Solubility ]
11 g/L (60 ºC) | [Detection Methods]
GC | [BRN ]
879910 | [CAS DataBase Reference]
121-50-6(CAS DataBase Reference) | [NIST Chemistry Reference]
Benzenamine, 2-chloro-5-(trifluoromethyl)-(121-50-6) | [Storage Precautions]
Light sensitive;Air sensitive | [EPA Substance Registry System]
121-50-6(EPA Substance) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi,N | [Risk Statements ]
R20/21/22:Harmful by inhalation, in contact with skin and if swallowed .
R51/53:Toxic to aquatic organisms, may cause long-term adverse effects in the aquatic environment .
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S36/37:Wear suitable protective clothing and gloves .
S60:This material and/or its container must be disposed of as hazardous waste .
S57:Use appropriate container to avoid environmental contamination .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
UN 2810 6.1/PG 3
| [WGK Germany ]
2
| [RTECS ]
XU5775000
| [Autoignition Temperature]
≥560°C | [Hazard Note ]
Irritant | [TSCA ]
Yes | [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29214300 |
| Hazard Information | Back Directory | [Chemical Properties]
CLEAR COLORLESS TO LIGHT YELLOW LIQUID | [Uses]
2-Chloro-5-trifluoromethylaniline | [Synthesis]
Example 1: N-methylpyrrolidone (1050 mL) was added to an autoclave with 102 g of anhydrous activated potassium fluoride followed by 377 g of 3,4-dichlorobenzotrifluoride. At ambient temperature, 158 g of ammonia was vented from a pressure tank into the reactor. The reaction mixture was heated to 245-250 °C over a period of 2 h, at which time the reactor pressure reached 30-32 kg/cm2. excess ammonia gas was continued to be passed from the pressure tank to maintain the reactor pressure at 38-40 kg/cm2 at a liquid temperature of 245-250 °C. The reaction was maintained at this temperature and pressure condition for 8 h. The reaction was completed with the addition of 377 g of potassium fluoride, followed by the addition of 377 g of 3,4-dichlorobenzotrifluoride. Upon completion of the reaction, the mixture was cooled to ambient temperature and the unreacted ammonia gas was drained and recovered. The reaction mixture was filtered and the products were separated by fractional distillation to give 2-chloro-4-trifluoromethylaniline (77% yield) and 2-chloro-5-trifluoromethylaniline (13% yield) based on 3,4-dichlorobenzotrifluoride consumption calculations. | [References]
[1] Patent: WO2011/107998, 2011, A1. Location in patent: Page/Page column 17
[2] Patent: US2013/30190, 2013, A1. Location in patent: Paragraph 0060 |
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