15263-75-9

14256-99-6

The general procedure for the synthesis of 4,6-dihydroxy-5-formylpyrimidines from N-((4-hydroxy-6-oxo-1,6-dihydropyrimidin-5-yl)methylene)-N-methylmethylammonium chloride was as follows: 30 mL of water was added to the reaction flask and stirring was initiated. The temperature of the reaction system was raised to 20-30 °C, followed by the addition of N-((4,6-dihydroxypyrimidin-5-yl)methylene)-N-methylmethylammonium chloride salt (10.0 g, 49.11 mmol). The reaction was kept at this temperature for 18 hours. After completion of the reaction, 50 mL of anhydrous ethanol was added to the mixture and stirring was continued. The reaction mixture was filtered and the resulting filter cake was washed with a small amount of anhydrous ethanol. Finally, the product was dried under vacuum at 40-45 °C to give 5.77 g of yellow solid.