| Identification | More | [Name]
(S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine | [CAS]
147081-44-5 | [Synonyms]
1-PYRROLIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER, (3S)-
(S)-(-)-1-BOC-3-AMINOPYRROLIDINE
(S)-1-BOC-3-AMINOPYRROLIDINE
(S)-(-)-1-TBOC-3-AMINOPYRROLIDINE
(s)-(-)-1-tert-butoxycarbonyl-3-aminopyrrolidine
(S)-3-AMINO-1-BOC-PYRROLIDINE
(S)-3-AMINO-1-N-BOC-PYRROLIDINE
(S)-3-AMINO-1-N-BOC-PYRROLIDINE CITRIC ACID SALT
(S)-3-AMINO-1-N-(T-BUTOXYCARBONYL)PYRROLIDINE
(S)-3-AMINO-1-TERT-BUTOXYCARBONYLPYRROLIDINE
(S)-3-AMINO-N-BOC-PYRROLIDINE
(S)-3-AMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
(S)-TERT-BUTYL 3-AMINOPYRROLIDINE-1-CARBOXYLATE
(s)-n-boc-3-aminopyrrolidine
(3S)-3-Amino-1-(tert-butoxycarbonyl)pyrrolidine
S-1-N-BOC-3-AMINO PYRROLIDINE
(3s)-(-)-1-(tert-butoxycarbonyl)-3-aminopyrrolidine
(3s)-(-)-1-boc-3-aminopyrrolidine
(3s)-(-)-3-amino-1-boc-pyrrolidine
(s)-n-boc-3-aminopyrrolidine(S)-1-Boc-3-Aminopyrrolidine | [EINECS(EC#)]
627-302-0 | [Molecular Formula]
C13H22N2O9 | [MDL Number]
MFCD08061976 | [Molecular Weight]
350.32 | [MOL File]
147081-44-5.mol |
| Chemical Properties | Back Directory | [Appearance]
Colorless to light yellow liqui | [alpha ]
-2 º (c=1, chloroform) | [Boiling point ]
216-217 °C(lit.)
| [density ]
1.067 g/mL at 25 °C(lit.)
| [refractive index ]
n20/D 1.4720(lit.)
| [Fp ]
196 °F
| [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [form ]
Liquid | [pka]
9.55±0.20(Predicted) | [color ]
Clear colorless to yellow | [Optical Rotation]
[α]20/D 2°, c = 1 in chloroform | [Sensitive ]
Air Sensitive | [BRN ]
8312125 | [InChI]
InChI=1S/C9H18N2O2/c1-9(2,3)13-8(12)11-5-4-7(10)6-11/h7H,4-6,10H2,1-3H3/t7-/m0/s1 | [InChIKey]
CMIBWIAICVBURI-ZETCQYMHSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CC[C@H](N)C1 | [CAS DataBase Reference]
147081-44-5(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,C,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R41:Risk of serious damage to eyes. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice . | [RIDADR ]
UN 2810 6.1/PG 3
| [WGK Germany ]
2
| [HazardClass ]
8 | [PackingGroup ]
III | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Colorless to light yellow liqui | [Uses]
(S)-(-)-1-Boc-3-aminopyrrolidine may be used to prepare:
- Descarboxamide analog of 4-N-(Nω-nitro-L-argininyl)-trans-4-amino-L-proline amide.
- Histamine 3 (H3) receptor antagonists containing pyrrolidin-3-yl-N-methylbenzamide moiety.
| [Synthesis]
To a solution of compound 178 (2.0 g, 9.42 mmol, 1.0 eq.) in methanol (40 mL) was added palladium carbon (1.0 g, 0.94 mmol, 0.1 eq.). The reaction mixture was subjected to hydrogenation at atmospheric pressure and room temperature for 6 hours. After completion of the reaction, the reaction mixture was filtered through diatomaceous earth and the filtrate was concentrated under reduced pressure. The target compound (S)-1-Boc-3-aminopyrrolidine was obtained as a yellow oil (1.7 g, 97% yield). | [References]
[1] Patent: US2009/221565, 2009, A1. Location in patent: Page/Page column 51
[2] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00470
[3] Patent: CN105399698, 2016, A. Location in patent: Paragraph 1340-1342
[4] Patent: WO2005/811, 2005, A1. Location in patent: Page/Page column 61
[5] Patent: WO2005/20975, 2005, A2. Location in patent: Page/Page column 221 |
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