| Identification | More | [Name]
4-Difluoromethoxy-3-hydroxybenzaldehyde | [CAS]
151103-08-1 | [Synonyms]
3-Hydroxy-4-diflouromethylbenzaldehyde
4-DIFLUOROMETHOXY-3-HYDROXYBENZALDEHYDE
4-(Difluoromethoxy)-3-hydroxybenzaldehyde 97%
4-(Difluoromethoxy)-3-hydroxybenzaldehyde97% | [EINECS(EC#)]
687-745-0 | [Molecular Formula]
C8H6F2O3 | [MDL Number]
MFCD04406687 | [Molecular Weight]
188.13 | [MOL File]
151103-08-1.mol |
| Chemical Properties | Back Directory | [Melting point ]
85-90°C | [Boiling point ]
280.6±35.0 °C(Predicted) | [density ]
1.395±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,2-8°C | [solubility ]
Chloroform (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
7.85±0.35(Predicted) | [color ]
White | [InChI]
InChI=1S/C8H6F2O3/c9-8(10)13-7-2-1-5(4-11)3-6(7)12/h1-4,8,12H | [InChIKey]
ZLIKNROJGXXNJG-UHFFFAOYSA-N | [SMILES]
C(=O)C1=CC=C(OC(F)F)C(O)=C1 | [CAS DataBase Reference]
151103-08-1(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection . | [WGK Germany ]
3 | [Hazard Note ]
Irritant | [HS Code ]
2913000090 |
| Hazard Information | Back Directory | [Description]
4-Difluoromethoxy-3-hydroxybenzaldehyde is an organofluorine compound, mainly used as an intermediate in organic synthesis. It is used in the synthesis of the impurity N-(3,5-dichloropyrid-4-yl)-4-difluoromethoxy-3-hydroxybenzamide isolated from roflumilast crude[1]. | [Chemical Properties]
4-Difluoromethoxy-3-hydroxybenzaldehyde is white powder
| [Uses]
4-Difluoromethoxy-3-hydroxybenzaldehyde is a phenyl alkyl ketone derivative used in the preparation of phosphodiesterase-4 (PDE4) inhibitors.
| [Synthesis]
Example 10 Preparation of 4-difluoromethoxy-3-hydroxybenzaldehyde: 3,4-dihydroxybenzaldehyde (0.50 g, 3.62 mmol, Aldrich), methyl 2-chloro-2,2-difluoroacetate (0.52 g, 3.62 mmol, Aldrich), and potassium carbonate (0.50 g, 3.62 mmol) were placed in argon- protected DMF ( 5.0 mL). The reaction mixture was stirred at 60°C to 65°C for 3 hours. Upon completion of the reaction, the DMF was removed by distillation under reduced pressure. the residue was subjected to liquid-liquid partitioning with 3N HCl aqueous solution and ether. The aqueous phase was extracted three times with ether. The combined organic phases were washed sequentially with water and saturated saline, dried over anhydrous magnesium sulfate and filtered, and the filtrate was concentrated under reduced pressure. The residue was purified by fast column chromatography (silica gel, 25% ethyl acetate/hexane) to afford the title compound 4-difluoromethoxy-3-hydroxybenzaldehyde as a white solid (0.20 g, 38% yield). Melting point 83°C to 85°C. | [References]
[1] YAN LIN. Isolation, synthesis and structure confirmation of the impurity in crude roflumilast product[J]. Research on Chemical Intermediates, 2012. DOI:10.1007/s11164-012-0823-3. |
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