| Identification | Back Directory | [Name]
- | [CAS]
1841134-72-2 | [Synonyms]
exo BCN-PEG3-NH2
BCN-exo-PEG3-NH2
exo BCN-PEG3-amine
BCN-PEG3-AMINE (EXO) | [Molecular Formula]
C19H32N2O5 | [MDL Number]
MFCD34470096 | [MOL File]
1841134-72-2.mol | [Molecular Weight]
368.47 |
| Chemical Properties | Back Directory | [Boiling point ]
519.6±40.0 °C(Predicted) | [density ]
1.14±0.1 g/cm3(Predicted) | [form ]
Liquid
(Density: 1.14±0.1 g/cm3) | [pka]
12.05±0.46(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
BCN- exo- PEG3- NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. BCN- exo- PEG3- NH2 is a click chemistry reagent, it contains a BCN group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups. | [Biological Activity]
BCN-?exo-?PEG3-?NH2 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | [IC 50]
PEGs | [References]
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 |
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