| Identification | More | [Name]
1-Boc-3-(Amino)azetidine | [CAS]
193269-78-2 | [Synonyms]
1-BOC-3-(AMINO)AZETIDINE
1-BOC-3-AMINOAZETIDINE HYDROCHLORIDE
3-AMINO-1-BOC-AZETIDINE
3-AMINO-1-N-BOC-AZETIDINE
3-AMINO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
3-AMINO-AZETIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER HYDROCHLORIDE
3-AMINOAZETIDINE, N1-BOC PROTECTED
TERT-BUTYL 3-AMINOAZETIDINE-1-CARBOXYLATE
1-N-Boc-3-aminoazetidine
3-amino-1-azetidinecarboxylate
3-Aminoazetidine, N1-BOC protected 97%
1-Boc-3-Aminoazatidine
3-AMINO-1-BOC-AZETIDINE 98%
N-BOC-3-AMINOAZETIDINE HYDROCHLORIDE
Boc-3-(Amino)azetidine | [EINECS(EC#)]
205-071-3 | [Molecular Formula]
C8H16N2O2 | [MDL Number]
MFCD01861753 | [Molecular Weight]
172.22 | [MOL File]
193269-78-2.mol |
| Chemical Properties | Back Directory | [Boiling point ]
79-81 3mm | [density ]
1.1g/ml | [refractive index ]
1.4650 | [storage temp. ]
Keep in dark place,Inert atmosphere,2-8°C | [solubility ]
DMSO, Methanol, Water | [form ]
Oil | [pka]
8.29±0.20(Predicted) | [color ]
Clear Colourless to Pale Yellow | [InChI]
InChI=1S/C8H16N2O2/c1-8(2,3)12-7(11)10-4-6(9)5-10/h6H,4-5,9H2,1-3H3 | [InChIKey]
WPGLRFGDZJSQGI-UHFFFAOYSA-N | [SMILES]
N1(C(OC(C)(C)C)=O)CC(N)C1 | [CAS DataBase Reference]
193269-78-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R34:Causes burns. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [RIDADR ]
2735 | [Hazard Note ]
Irritant | [HazardClass ]
8 | [HazardClass ]
IRRITANT | [PackingGroup ]
Ⅲ | [HS Code ]
29339900 |
| Hazard Information | Back Directory | [Chemical Properties]
Clear Colourless to Pale Yellow Oil | [Synthesis]
General procedure for the synthesis of tert-butyl 3-aminoazetidine-1-carboxylate from 1-BOC-3-azidoazetidine: tert-butyl 3-azidoazetidine-1-carboxylate (0.420 g, 2.19 mmol) was dissolved in EtOAc (20 mL) and 10% Pd/C (100 mg) was added. The reaction mixture was stirred under hydrogen atmosphere (balloon). After 12 h of reaction, the catalyst was removed by filtration through a diatomaceous earth pad. The filtrate was concentrated in vacuum to give a colorless oily product (1.76 g, 99% yield), which could be used in subsequent reactions without further purification.1H NMR (CDCl3): δ 1.50 (s, 9H). | [References]
[1] Patent: WO2004/74283, 2004, A1. Location in patent: Page 40
[2] Patent: US2011/166121, 2011, A1. Location in patent: Page/Page column 56
[3] Patent: US2003/229226, 2003, A1. Location in patent: Page 21-22 |
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