| Identification | More | [Name]
3-(3-CHLOROPHENYL)PROPIONIC ACID | [CAS]
21640-48-2 | [Synonyms]
3-(3-CHLOROPHENYL)PROPANOIC ACID
3-(3-CHLOROPHENYL)PROPIONIC ACID
ASINEX-REAG BAS 10861260
TIMTEC-BB SBB005906
3-Chlorobenzenepropanoic acid | [EINECS(EC#)]
626-900-9 | [Molecular Formula]
C9H9ClO2 | [MDL Number]
MFCD01310801 | [Molecular Weight]
184.62 | [MOL File]
21640-48-2.mol |
| Chemical Properties | Back Directory | [Melting point ]
72-76 °C (lit.) | [Boiling point ]
263.86°C (rough estimate) | [density ]
1.1989 (rough estimate) | [refractive index ]
1.5242 (estimate) | [storage temp. ]
Sealed in dry,Room Temperature | [form ]
solid | [pka]
4.59(at 25℃) | [Appearance]
White to off-white Solid | [CAS DataBase Reference]
21640-48-2(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xn,Xi | [Risk Statements ]
R22:Harmful if swallowed.
R41:Risk of serious damage to eyes.
R43:May cause sensitization by skin contact. | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S39:Wear eye/face protection . | [WGK Germany ]
3
| [Hazard Note ]
Irritant | [HazardClass ]
IRRITANT | [HS Code ]
29163990 |
| Hazard Information | Back Directory | [Chemical Properties]
White to brown powder | [Synthesis]
B. The reaction solution from step A was transferred to a 2L four-necked flask and 60.0 g of sodium hydroxide solid was added and stirred thoroughly until completely dissolved. Subsequently, the reaction mixture was slowly heated to 60-65°C and maintained at this temperature for about 3 hours. The reaction progress was monitored by gas chromatography (GC), and after confirming that the reaction endpoint was reached, the reaction solution was cooled to 20 °C. After standing and layering, the aqueous phase was separated and slowly added to 190.1 g of 30% aqueous hydrochloric acid and the pH was adjusted to about 3.0. The organic phase was collected by standing and layering again. The organic phase was dried over anhydrous sodium sulfate to give 143.2 g of the target product 3-(3-chlorophenyl)propionic acid in 77.6% yield. | [References]
[1] Patent: CN108329197, 2018, A. Location in patent: Paragraph 0107; 0110 |
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