| Identification | More | [Name]
2-Amino-4-methylbenzoic acid | [CAS]
2305-36-4 | [Synonyms]
2-AMINO-4-METHYLBENZOIC ACID
4-METHYLANTHRANILIC ACID
RARECHEM AL BO 0820
Benzoic acid, 2-amino-4-methyl-
Benzoic acid, 2-amino-4-methyl-(9CI) | [EINECS(EC#)]
218-976-3 | [Molecular Formula]
C8H9NO2 | [MDL Number]
MFCD00047853 | [Molecular Weight]
151.16 | [MOL File]
2305-36-4.mol |
| Chemical Properties | Back Directory | [Melting point ]
160 °C | [Boiling point ]
329.8±30.0 °C(Predicted) | [density ]
1.254±0.06 g/cm3(Predicted) | [storage temp. ]
Keep in dark place,Inert atmosphere,Room temperature | [solubility ]
DMSO (Slightly), Methanol (Slightly) | [form ]
Solid | [pka]
5.11±0.10(Predicted) | [color ]
Off-White to Light Brown | [InChI]
InChI=1S/C8H9NO2/c1-5-2-3-6(8(10)11)7(9)4-5/h2-4H,9H2,1H3,(H,10,11) | [InChIKey]
RPGKFFKUTVJVPY-UHFFFAOYSA-N | [SMILES]
C(O)(=O)C1=CC=C(C)C=C1N | [CAS DataBase Reference]
2305-36-4(CAS DataBase Reference) | [NIST Chemistry Reference]
P-toluic acid, 2-amino-(2305-36-4) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S37/39:Wear suitable gloves and eye/face protection . | [Hazard Note ]
Irritant | [HS Code ]
29224999 |
| Hazard Information | Back Directory | [Chemical Properties]
Light cream solid | [Uses]
2-Amino-4-methylbenzoic Acid performs a herbicidal function in Agriculture. A plant growth-regulator. | [Definition]
ChEBI: 2-Amino-4-methylbenzoic acid is an aminobenzoic acid. | [Synthesis]
The general procedure for the synthesis of 2-amino-4-methylbenzoic acid from 2-bromo-5-methylaniline was as follows: 2-bromo-5-methylaniline (10.0 g, 53.7 mmol) was dissolved in anhydrous ethyl ether (500 mL) under protection of nitrogen atmosphere, cooled to -78 °C and stirred. Tert-butyl lithium (127 mL, 1.7 M solution, 214.8 mmol) in pentane was added slowly over 15 minutes, keeping the reaction temperature from exceeding -65 °C. After addition, stirring was continued at -78°C for 1.5 hours. Subsequently, the reaction was quenched with excess crushed dry ice (solid CO2). After complete evaporation of the dry ice, water was added to the reaction mixture and the organic layer was separated and discarded. The aqueous layer was acidified with 1N hydrochloric acid and then extracted with two parts of ethyl acetate. The organic extracts were combined, dried with anhydrous magnesium sulfate, filtered and concentrated to give the target product 2-amino-4-methylbenzoic acid (4.8 g, 59% yield) as a tan crystalline solid. Mass spectrum (chemical ionization): 152 (M+H). | [References]
[1] Patent: US5599814, 1997, A |
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